daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

daf-16/FoxO is required to survive starvation in Caenorhabditis elegans, but how daf-16IFoxO promotes starvation resistance is unclear. We show that daf-16/FoxO restructures carbohydrate metabolism by driving carbon flux through the glyoxylate shunt and gluconeogenesis and into synthesis of trehalos...

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Publicat a:eLife
Autors principals: Hibshman, Jonathan D, Doan, Alexander E, Moore, Brad T, Kaplan, Rebecca EW, Hung, Anthony, Webster, Amy K, Bhatt, Dhaval P, Chitrakar, Rojin, Hirschey, Matthew D, Baugh, L Ryan
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Biochemistry and Chemical Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655125/
https://ncbi.nlm.nih.gov/pubmed/29063832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30057
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