Hyperbaric Oxygen Sensitizes Anoxic Pseudomonas aeruginosa Biofilm to Ciprofloxacin

Chronic Pseudomonas aeruginosa lung infection is characterized by the presence of endobronchial antibiotic-tolerant biofilm, which is subject to strong oxygen (O(2)) depletion due to the activity of surrounding polymorphonuclear leukocytes. The exact mechanisms affecting the antibiotic susceptibilit...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Kolpen, Mette, Lerche, Christian J., Kragh, Kasper N., Sams, Thomas, Koren, Klaus, Jensen, Anna S., Line, Laura, Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus, Kühl, Michael, Høiby, Niels, Jensen, Peter Ø.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655102/
https://ncbi.nlm.nih.gov/pubmed/28874373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01024-17
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