Using Population Pharmacokinetic Modeling and Monte Carlo Simulations To Determine whether Standard Doses of Piperacillin in Piperacillin-Tazobactam Regimens Are Adequate for the Management of Febrile Neutropenia

Changes in the pharmacokinetics of piperacillin in febrile neutropenic patients have been reported to result in suboptimal exposures. This study aimed to develop a population pharmacokinetic model for piperacillin and perform dosing simulation to describe optimal dosing regimens for hematological ma...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Sime, Fekade Bruck, Hahn, Uwe, Warner, Morgyn S., Tiong, Ing Soo, Roberts, Michael S., Lipman, Jeffrey, Peake, Sandra L., Roberts, Jason A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655099/
https://ncbi.nlm.nih.gov/pubmed/28807922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00311-17
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