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Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes

A classical model for allosteric regulation of enzyme activity posits an equilibrium between inactive and active conformations. An alternative view is that allosteric activation is achieved by increasing the potential for conformational changes that are essential for catalysis. In the present study,...

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Publicado en:Protein Sci
Autores principales: Endrizzi, James A., Beernink, Peter T.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654843/
https://ncbi.nlm.nih.gov/pubmed/28833948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3277
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