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Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes

A classical model for allosteric regulation of enzyme activity posits an equilibrium between inactive and active conformations. An alternative view is that allosteric activation is achieved by increasing the potential for conformational changes that are essential for catalysis. In the present study,...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Endrizzi, James A., Beernink, Peter T.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654843/
https://ncbi.nlm.nih.gov/pubmed/28833948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3277
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