Mouse models of acute and chronic hepacivirus infection

An estimated 71 million people worldwide are infected with hepatitis C virus (HCV). The lack of small animal models has impeded studies of antiviral immune mechanisms. Here we show that an HCV-related hepacivirus discovered in Norway rats can establish high titer hepatotropic infections in laborator...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Billerbeck, Eva, Wolfisberg, Raphael, Fahnøe, Ulrik, Xiao, Jing W., Quirk, Corrine, Luna, Joseph M., Cullen, John M., Hartlage, Alex S., Chiriboga, Luis, Ghoshal, Kalpana, Lipkin, W. Ian, Bukh, Jens, Scheel, Troels K. H., Kapoor, Amit, Rice, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654634/
https://ncbi.nlm.nih.gov/pubmed/28706073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal1962
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