Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma

BACKGROUND: Platelet-derived growth factor receptor A is altered by amplification and/or mutation in diffuse intrinsic pontine glioma (DIPG). We explored in vitro on new DIPG models the efficacy of dasatinib, a multi-tyrosine kinase inhibitor targeting this receptor. METHODS: Gene expression profile...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Truffaux, Nathalène, Philippe, Cathy, Paulsson, Janna, Andreiuolo, Felipe, Guerrini-Rousseau, Léa, Cornilleau, Gaétan, Le Dret, Ludivine, Richon, Catherine, Lacroix, Ludovic, Puget, Stéphanie, Geoerger, Birgit, Vassal, Gilles, Östman, Arne, Grill, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654348/
https://ncbi.nlm.nih.gov/pubmed/25534822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou330
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