Physicochemical characterisation, immunogenicity and protective efficacy of a lead streptococcal vaccine: progress towards Phase I trial

Globally, group A streptococcal infections are responsible for over 500,000 deaths per year. A safe vaccine that does not induce autoimmune pathology and that affords coverage for most GAS serotypes is highly desired. We have previously demonstrated that a vaccine based on the conserved M-protein ep...

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Опубликовано в: :Sci Rep
Главные авторы: Pandey, Manisha, Powell, Jessica, Calcutt, Ainslie, Zaman, Mehfuz, Phillips, Zachary N., Ho, Mei Fong, Batzloff, Michael R., Good, Michael F.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653875/
https://ncbi.nlm.nih.gov/pubmed/29062085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14157-7
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