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In silico screening for identification of pyrrolidine derivatives dipeptidyl peptidase-IV inhibitors using COMFA, CoMSIA, HQSAR and docking studies

To explore the relationship between the structures of substituted pyrrolidine derivatives and their inhibition of dipeptidyl peptidase IV inhibitors. The QSAR, including CoMFA, CoMSIA and HQSAR, were applied to identify the key structures impacting their inhibitory potencies. The CoMFA, CoMSIA and H...

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Publicat a:In Silico Pharmacol
Autors principals: Sharma, M. C., Jain, S., Sharma, R.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653681/
https://ncbi.nlm.nih.gov/pubmed/29098139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40203-017-0032-2
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