Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival

B cell activation is dependent on a large increase in transcriptional output followed by focused expression on secreted immunoglobulin as the cell transitions to an antibody producing plasma cell. The rapid transcriptional induction is facilitated by the release of poised RNA pol II into productive...

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Pubblicato in:Mol Immunol
Autori principali: Alexander, Lou-Ella M.M, Watters, January, Reusch, Jessica A., Maurin, Michelle, Nepon-Sixt, Brook S., Vrzalikova, Katerina, Alexandrow, Mark G., Murray, Paul G., Wright, Kenneth L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653440/
https://ncbi.nlm.nih.gov/pubmed/28858629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2017.08.016
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