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Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats

The locus coeruleus (LC) projects throughout the brain and spinal cord and is the major source of central noradrenaline. It remains unclear whether the LC acts functionally as a single global effector or as discrete modules. Specifically, while spinal-projections from LC neurons can exert analgesic...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hirschberg, Stefan, Li, Yong, Randall, Andrew, Kremer, Eric J, Pickering, Anthony E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653237/
https://ncbi.nlm.nih.gov/pubmed/29027903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29808
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