Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke

INTRODUCTION: Acute ischemic injury leads to severe neuronal loss. One of the key mechanisms responsible for this effect is inflammation, which is characterized by the activation of myeloid cells, including resident microglia and infiltrating monocytes/macrophages. P2X4 receptors (P2X4Rs) present on...

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Udgivet i:Brain Behav Immun
Main Authors: Verma, Rajkumar, Cronin, Chunxia G., Hudobenko, Jacob, Venna, Venugopal R., McCullough, Louise D., Liang, Bruce T.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650951/
https://ncbi.nlm.nih.gov/pubmed/28751018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2017.07.155
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