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Monitoring immune-checkpoint blockade: response evaluation and biomarker development

Cancer immunotherapy using immune-checkpoint blockade (ICB) has created a paradigm shift in the treatment of advanced-stage cancers. The promising antitumour activity of monoclonal antibodies targeting the immune-checkpoint proteins CTLA-4, PD-1, and PD-L1 led to regulatory approvals of these agents...

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Bibliografske podrobnosti
izdano v:Nat Rev Clin Oncol
Main Authors: Nishino, Mizuki, Ramaiya, Nikhil H., Hatabu, Hiroto, Hodi, F. Stephen
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650537/
https://ncbi.nlm.nih.gov/pubmed/28653677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrclinonc.2017.88
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