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A placebo-controlled Bayesian dose finding design based on continuous reassessment method with application to stroke research
Traditional dose-finding designs do not require assignment of patients to a control group. Motivated by SHRINC (Safety of Pioglitazone for hematoma resolution in intracerebral hemorrhage), we developed a placebo-controlled dose-finding study to identify the maximum tolerated dose for pioglitazone in...
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| Publicado en: | Contemp Clin Trials Commun |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5650116/ https://ncbi.nlm.nih.gov/pubmed/29062975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conctc.2017.05.002 |
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