Novel Interactions between Gut Microbiome and Host Drug-Processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals Polybrominated Diphenyl Ethers

The gut microbiome is a novel frontier in xenobiotic metabolism. Polybrominated diphenyl ethers (PBDEs), especially BDE-47 (2, 2′, 4, 4′-tetrabromodiphenyl ether) and BDE-99 (2, 2′, 4, 4′,5-pentabromodiphenyl ether), are among the most abundant and persistent environmental contaminants that produce...

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Publicado no:Drug Metab Dispos
Main Authors: Li, Cindy Yanfei, Lee, Soowan, Cade, Sara, Kuo, Li-Jung, Schultz, Irvin R., Bhatt, Deepak K., Prasad, Bhagwat, Bammler, Theo K., Cui, Julia Yue
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649562/
https://ncbi.nlm.nih.gov/pubmed/28864748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.077024
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