Phase 1 clinical trial using mbIL21 ex vivo–expanded donor-derived NK cells after haploidentical transplantation

Relapse has emerged as the most important cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HSCT). To test the hypothesis that natural killer (NK) cells can decrease the risk of leukemia relapse, we initiated a phase 1 dose-escalation study of membrane-bound interl...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ciurea, Stefan O., Schafer, Jolie R., Bassett, Roland, Denman, Cecele J., Cao, Kai, Willis, Dana, Rondon, Gabriela, Chen, Julianne, Soebbing, Doris, Kaur, Indreshpal, Gulbis, Alison, Ahmed, Sairah, Rezvani, Katayoun, Shpall, Elizabeth J., Lee, Dean A., Champlin, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649552/
https://ncbi.nlm.nih.gov/pubmed/28835441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-785659
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