Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling

Microglia activation and associated inflammatory response are involved in the pathogenesis of different neurodegenerative diseases. We have reported that Notch-1 and NF-κB/p65 signalling pathways operate in synergy in regulating the production of proinflammatory mediators in activated microglia. In...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cao, Qiong, Karthikeyan, Aparna, Dheen, S. Thameem, Kaur, Charanjit, Ling, Eng-Ang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648239/
https://ncbi.nlm.nih.gov/pubmed/29049420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186764
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