Metastability Gap in the Phase Diagram of Monoclonal IgG Antibody

Crystallization of IgG antibodies has important applications in the fields of structural biology, biotechnology, and biopharmaceutics. However, a rational approach to crystallize antibodies is still lacking. In this work, we report a method to estimate the solubility of antibodies at various tempera...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Rowe, Jacob B., Cancel, Rachel A., Evangelous, Tyler D., Flynn, Rhiannon P., Pechenov, Sergei, Subramony, J. Anand, Zhang, Jifeng, Wang, Ying
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2017
Fag:
Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647622/
https://ncbi.nlm.nih.gov/pubmed/29045869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.048
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