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Facilitating identification of minimal protein binding domains by cross-linking mass spectrometry

Characterization of protein interaction domains is crucial for understanding protein functions. Here we combine cross-linking mass spectrometry (XL-MS) with deletion analysis to accurately locate minimal protein interaction domains. As a proof of concept, we investigated in detail the binding interf...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liu, Qingyang, Remmelzwaal, Sanne, Heck, Albert J. R., Akhmanova, Anna, Liu, Fan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647383/
https://ncbi.nlm.nih.gov/pubmed/29044157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13663-y
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