Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine

Agmatine N-acetyltransferase (AgmNAT) catalyzes the formation of N-acetylagmatine from acetyl-CoA and agmatine. Herein, we provide evidence that Drosophila melanogaster AgmNAT (CG15766) catalyzes the formation of N-acetylagmatine using an ordered sequential mechanism; acetyl-CoA binds prior to agmat...

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Publicado no:Sci Rep
Main Authors: Dempsey, Daniel R., Nichols, Derek A., Battistini, Matthew R., Pemberton, Orville, Ospina, Santiago Rodriguez, Zhang, Xiujun, Carpenter, Anne-Marie, O’Flynn, Brian G., Leahy, James W., Kanwar, Ankush, Lewandowski, Eric M., Chen, Yu, Merkler, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647378/
https://ncbi.nlm.nih.gov/pubmed/29044148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13669-6
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