Targeting the GM-CSF receptor for the treatment of CNS autoimmunity

In multiple sclerosis (MS), there is a growing interest in inhibiting the pro-inflammatory effects of granulocyte-macrophage colony-stimulating factor (GM-CSF). We sought to evaluate the therapeutic potential and underlying mechanisms of GM-CSF receptor alpha (Rα) blockade in animal models of MS. We...

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Gepubliceerd in:J Autoimmun
Hoofdauteurs: Ifergan, Igal, Davidson, Todd S., Kebir, Hania, Xu, Dan, Palacios-Macapagal, Daphne, Cann, Jennifer, Rodgers, Jane M., Hunter, Zoe N., Pittet, Camille L., Beddow, Sara, Jones, Clare A., Prat, Alexandre, Sleeman, Matthew A., Miller, Stephen D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647260/
https://ncbi.nlm.nih.gov/pubmed/28641926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2017.06.005
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