Differential binding of tetrodotoxin and its derivatives to voltage‐sensitive sodium channel subtypes (Na(v)1.1 to Na(v)1.7)

BACKGROUND AND PURPOSE: The development of subtype‐selective ligands to inhibit voltage‐sensitive sodium channels (VSSCs) has been attempted with the aim of developing therapeutic compounds. Tetrodotoxin (TTX) is a toxin from pufferfish that strongly inhibits VSSCs. Many TTX analogues have been iden...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Tsukamoto, Tadaaki, Chiba, Yukie, Wakamori, Minoru, Yamada, Tomoshi, Tsunogae, Shunsuke, Cho, Yuko, Sakakibara, Ryo, Imazu, Takuya, Tokoro, Shouta, Satake, Yoshiki, Adachi, Masaatsu, Nishikawa, Toshio, Yotsu‐Yamashita, Mari, Konoki, Keiichi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647187/
https://ncbi.nlm.nih.gov/pubmed/28832970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13985
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