Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells

Numerous clinical studies have reported that statins increase the plasma concentration of arachidonic acid, which is an ω-6 long-chain polyunsaturated fatty acid (LCPUFA), and decrease the concentrations of eicosapentaenoic acid and docosahexaenoic acid, which are ω-3 LCPUFAs. These findings indicat...

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Vydáno v:Mol Med Rep
Hlavní autoři: Ishihara, Noriko, Suzuki, Sawako, Tanaka, Shou, Watanabe, Yasuhiro, Nagayama, Daiji, Saiki, Atsuhito, Tanaka, Tomoaki, Tatsuno, Ichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647059/
https://ncbi.nlm.nih.gov/pubmed/28765914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.7141
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