CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases

The immune checkpoint receptor CTLA-4 plays a crucial part in negatively regulating T cell activation and maintaining self-tolerance. It is frequently overexpressed in a variety of malignancies, yet its prognostic impact in non-small cell lung cancer (NSCLC) remains unclear. We constructed tissue mi...

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Publicat a:Cancer Immunol Immunother
Autors principals: Paulsen, Erna-Elise, Kilvaer, Thomas K., Rakaee, Mehrdad, Richardsen, Elin, Hald, Sigurd M., Andersen, Sigve, Busund, Lill-Tove, Bremnes, Roy M., Donnem, Tom
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645427/
https://ncbi.nlm.nih.gov/pubmed/28707078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-017-2039-2
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