Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells

We examined the impact of crosstalk between the insulin receptor (INSR) and G protein-coupled receptor (GPCR) signaling pathways on the regulation of Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in the context of human pancreatic ductal adenocarcinoma (PDAC...

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Vydáno v:Mol Cancer Res
Hlavní autoři: Hao, Fang, Xu, Qinhong, Zhao, Yinglan, Stevens, Jan V., Young, Steven H., Sinnett-Smith, James, Rozengurt, Enrique
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645013/
https://ncbi.nlm.nih.gov/pubmed/28360038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0023
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