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Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine
N (ε)-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N (ε)-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic...
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| Pubblicato in: | Chem Commun (Camb) |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5644716/ https://ncbi.nlm.nih.gov/pubmed/27965989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc08381a |
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