The safety profile of parecoxib for the treatment of postoperative pain: a pooled analysis of 28 randomized, double-blind, placebo-controlled clinical trials and a review of over 10 years of postauthorization data

BACKGROUND: Nonselective, nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 (COX-2) inhibitors are associated with safety issues including cardiovascular, renal, and gastrointestinal (GI) events. OBJECTIVE: To examine the safety of parecoxib, a COX-2 inhibitor, for the man...

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Veröffentlicht in:J Pain Res
Hauptverfasser: Schug, Stephan A, Parsons, Bruce, Li, Chunming, Xia, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5644539/
https://ncbi.nlm.nih.gov/pubmed/29066931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S136052
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