Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing

Recognition of individuals with a genetic predisposition to gastric cancer (GC) enables preventive measures. However, the underlying cause of genetic susceptibility to gastric cancer remains largely unexplained. We performed germline whole-exome sequencing on leukocyte DNA of 54 patients from 53 fam...

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Detalhes bibliográficos
Publicado no:Eur J Hum Genet
Main Authors: Vogelaar, Ingrid P, van der Post, Rachel S, van Krieken, J Han JM, Spruijt, Liesbeth, van Zelst-Stams, Wendy AG, Kets, C Marleen, Lubinski, Jan, Jakubowska, Anna, Teodorczyk, Urszula, Aalfs, Cora M, van Hest, Liselotte P, Pinheiro, Hugo, Oliveira, Carla, Jhangiani, Shalini N, Muzny, Donna M, Gibbs, Richard A, Lupski, James R, de Ligt, Joep, Vissers, Lisenka E L M, Hoischen, Alexander, Gilissen, Christian, van de Vorst, Maartje, Goeman, Jelle J, Schackert, Hans K, Ranzani, Guglielmina N, Molinaro, Valeria, Gómez García, Encarna B, Hes, Frederik J, Holinski-Feder, Elke, Genuardi, Maurizio, Ausems, Margreet G E M, Sijmons, Rolf H, Wagner, Anja, van der Kolk, Lizet E, Bjørnevoll, Inga, Høberg-Vetti, Hildegunn, van Kessel, Ad Geurts, Kuiper, Roland P, Ligtenberg, Marjolijn J L, Hoogerbrugge, Nicoline
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643972/
https://ncbi.nlm.nih.gov/pubmed/28875981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2017.138
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