Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives

The main objective of this work was to synthesize novel compounds with a benzo[de][1,2,4]triazolo[5,1-a]isoquinoline scaffold by employing (dioxo-benzo[de]isoquinolin-2-yl) thiourea as a building block. Molecular docking was conducted in the COX-2 active site to predict the plausible binding mode an...

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Detalhes bibliográficos
Publicado no:Chem Cent J
Main Authors: Abuelizz, Hatem A., Al-Salahi, Rashad, Al-Asri, Jamil, Mortier, Jérémie, Marzouk, Mohamed, Ezzeldin, Essam, Ali, Azza A., Khalil, Mona G., Wolber, Gerhard, Ghabbour, Hazem A., Almehizia, Abdulrahman A., Abdel Jaleel, Gehad A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643734/
https://ncbi.nlm.nih.gov/pubmed/29086866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-017-0321-1
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