Effects of charge-modifying mutations in histone H2A α3-domain on nucleosome stability assessed by single-pair FRET and MD simulations

Nucleosomes are important for chromatin compaction and gene regulation; their integrity depends crucially on the structural properties of the histone tails. Recent all-atom molecular dynamics simulations revealed that removal of the N-terminal tails of histone H3, known to destabilize nucleosomes, c...

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Published in:Sci Rep
Main Authors: Lehmann, Kathrin, Zhang, Ruihan, Schwarz, Nathalie, Gansen, Alexander, Mücke, Norbert, Langowski, Jörg, Toth, Katalin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643395/
https://ncbi.nlm.nih.gov/pubmed/29038501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13416-x
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