Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway

AIM: To determine whether Nucb2/nesfatin1 production is regulated by the cannabinoid system through the intracellular mTOR pathway in the stomach. METHODS: Sprague Dawley rats were treated with vehicle, rimonabant, rapamycin or rapamycin+rimonabant. Gastric tissue obtained from the animals was used...

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Enregistré dans:
Détails bibliographiques
Publié dans:World J Gastroenterol
Auteurs principaux: Folgueira, Cintia, Barja-Fernandez, Silvia, Prado, Laura, Al-Massadi, Omar, Castelao, Cecilia, Pena-Leon, Veronica, Gonzalez-Saenz, Patricia, Baltar, Javier, Baamonde, Ivan, Leis, Rosaura, Dieguez, Carlos, Pagotto, Uberto, Casanueva, Felipe F, Tovar, Sulay A, Nogueiras, Ruben, Seoane, Luisa M
Format: Artigo
Langue:Inglês
Publié: Baishideng Publishing Group Inc 2017
Sujets:
Basic Study
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643265/
https://ncbi.nlm.nih.gov/pubmed/29085189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v23.i35.6403
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