Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation and less remyelination following cuprizone exposure

The TAM (Tyro3, Axl, and MerTK) family of receptor tyrosine kinases (RTKs) and their ligands, Gas6 and ProS1, are important for innate immune responses and central nervous system (CNS) homeostasis. While only Gas6 directly activates Axl, ProS1 activation of Tyro3/MerTK can indirectly activate Axl th...

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Pubblicato in:Glia
Autori principali: Ray, Alex K., DuBois, Juwen C., Gruber, Ross C., Guzik, Hillary M., Gulinello, Maria E., Perumal, Geoffrey, Raine, Cedric, Kozakiewicz, Lauren, Williamson, Julie, Shafit-Zagardo, Bridget
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643251/
https://ncbi.nlm.nih.gov/pubmed/28925029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23214
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