Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation and less remyelination following cuprizone exposure

The TAM (Tyro3, Axl, and MerTK) family of receptor tyrosine kinases (RTKs) and their ligands, Gas6 and ProS1, are important for innate immune responses and central nervous system (CNS) homeostasis. While only Gas6 directly activates Axl, ProS1 activation of Tyro3/MerTK can indirectly activate Axl th...

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Bibliografski detalji
Izdano u:Glia
Glavni autori: Ray, Alex K., DuBois, Juwen C., Gruber, Ross C., Guzik, Hillary M., Gulinello, Maria E., Perumal, Geoffrey, Raine, Cedric, Kozakiewicz, Lauren, Williamson, Julie, Shafit-Zagardo, Bridget
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643251/
https://ncbi.nlm.nih.gov/pubmed/28925029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23214
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