Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies

Herpesvirus entry into cells requires the coordinated action of multiple virus envelope glycoproteins, including gH, gL, and gB. For EBV, the gp42 protein assembles into complexes with gHgL heterodimers and binds HLA class II to activate gB-mediated membrane fusion with B cells. EBV tropism is dicta...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Sathiyamoorthy, Karthik, Jiang, Jiansen, Möhl, Britta S., Chen, Jia, Zhou, Z. Hong, Longnecker, Richard, Jardetzky, Theodore S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642686/
https://ncbi.nlm.nih.gov/pubmed/28939750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704661114
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