Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies

Herpesvirus entry into cells requires the coordinated action of multiple virus envelope glycoproteins, including gH, gL, and gB. For EBV, the gp42 protein assembles into complexes with gHgL heterodimers and binds HLA class II to activate gB-mediated membrane fusion with B cells. EBV tropism is dicta...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sathiyamoorthy, Karthik, Jiang, Jiansen, Möhl, Britta S., Chen, Jia, Zhou, Z. Hong, Longnecker, Richard, Jardetzky, Theodore S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642686/
https://ncbi.nlm.nih.gov/pubmed/28939750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704661114
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