Opposing roles of ICAT and Wnt/β-catenin signaling in NSC67657-induced monocytic differentiation

NSC67657 is a new steroid drug that induces monocytic differentiation of acute myeloid leukemia cells. Here, we demonstrate that NSC67657 has opposing effects on expression of downstream targets of inhibitor of β-catenin and TCF (ICAT) and Wnt signaling in HL60 cells. ICAT binds to β-catenin, and th...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Wang, Weijia, Zhang, Yan, Yuan, Yong, Yuan, Runqiang, Yang, Youye, Zhang, Xiuming, Wen, Dongmei, Huang, Fuda, Wang, Jinshu
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642527/
https://ncbi.nlm.nih.gov/pubmed/29050252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19457
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