Teriflunomide restores 5-azacytidine sensitivity via activation of pyrimidine salvage in 5-azacytidine-resistant leukemia cells

Previous studies showed that downregulation of pyrimidine salvage underlies resistance against 5-azacytidine (AZA), indicating an important role for de novo pyrimidine synthesis in AZA resistance. Because de novo pyrimidine synthesis is inhibited by the immunomodulator teriflunomide and its pro-drug...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Imanishi, Satoshi, Takahashi, Ryoko, Katagiri, Seiichiro, Kobayashi, Chiaki, Umezu, Tomohiro, Ohyashiki, Kazuma, Ohyashiki, Junko H.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642525/
https://ncbi.nlm.nih.gov/pubmed/29050250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19436
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