Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril

The chemoenzymatic flow synthesis of enantiomerically pure captopril, a widely used antihypertensive drug, is accomplished starting from simple, inexpensive, and readily available reagents. The first step is a heterogeneous biocatalyzed regio‐ and stereoselective oxidation of cheap prochiral 2‐methy...

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Veröffentlicht in:ChemistryOpen
Hauptverfasser: De Vitis, Valerio, Dall'Oglio, Federica, Pinto, Andrea, De Micheli, Carlo, Molinari, Francesco, Conti, Paola, Romano, Diego, Tamborini, Lucia
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641918/
https://ncbi.nlm.nih.gov/pubmed/29046862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201700082
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