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Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril
The chemoenzymatic flow synthesis of enantiomerically pure captopril, a widely used antihypertensive drug, is accomplished starting from simple, inexpensive, and readily available reagents. The first step is a heterogeneous biocatalyzed regio‐ and stereoselective oxidation of cheap prochiral 2‐methy...
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| Pubblicato in: | ChemistryOpen |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5641918/ https://ncbi.nlm.nih.gov/pubmed/29046862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201700082 |
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