Proteolytic cleavage by the inner membrane peptidase (IMP) complex or Oct1 peptidase controls the localization of the yeast peroxiredoxin Prx1 to distinct mitochondrial compartments

Yeast Prx1 is a mitochondrial 1-Cys peroxiredoxin that catalyzes the reduction of endogenously generated H(2)O(2). Prx1 is synthesized on cytosolic ribosomes as a preprotein with a cleavable N-terminal presequence that is the mitochondrial targeting signal, but the mechanisms underlying Prx1 distrib...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Gomes, Fernando, Palma, Flávio Romero, Barros, Mario H., Tsuchida, Eduardo T., Turano, Helena G., Alegria, Thiago G. P., Demasi, Marilene, Netto, Luis E. S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641892/
https://ncbi.nlm.nih.gov/pubmed/28821623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788588
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