ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

APOE4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). ApoE4 increases brain amyloid-β (Aβ) pathology relative to other ApoE isoforms(1). However, whether APOE independently influences tau pathology, the other major proteinopathy of AD and other tauopathies, or tau-media...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Shi, Yang, Yamada, Kaoru, Liddelow, Shane Antony, Smith, Scott T, Zhao, Lingzhi, Luo, Wenjie, Tsai, Richard M., Spina, Salvatore, Grinberg, Lea T., Rojas, Julio C., Gallardo, Gilbert, Wang, Kairuo, Roh, Joseph, Robinson, Grace, Finn, Mary Beth, Jiang, Hong, Sullivan, Patrick M, Baufeld, Caroline, Wood, Michael W., Sutphen, Courtney, McCue, Lena, Xiong, Chengjie, Del-Aguila, Jorge L., Morris, John C., Cruchaga, Carlos, Fagan, Anne M., Miller, Bruce L., Boxer, Adam L., Seeley, William W., Butovsky, Oleg, Barres, Ben A., Paul, Steven M., Holtzman, David M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641217/
https://ncbi.nlm.nih.gov/pubmed/28959956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24016
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