HIV Fusion in Dendritic Cells Occurs Mainly at the Surface and Is Limited by Low CD4 Levels

HIV-1 poorly infects monocyte-derived dendritic cells (MDDCs). This is in large part due to SAMHD1, which restricts viral reverse transcription. Pseudotyping HIV-1 with vesicular stomatitis virus G protein (VSV-G) strongly enhances infection, suggesting that earlier steps of viral replication, inclu...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Chauveau, Lise, Donahue, Daniel Aaron, Monel, Blandine, Porrot, Francoise, Bruel, Timothée, Richard, Lea, Casartelli, Nicoletta, Schwartz, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640872/
https://ncbi.nlm.nih.gov/pubmed/28814521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01248-17
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