TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival

Mutations in the tRNA methyltransferase 1 (TRMT1) gene have been identified as the cause of certain forms of autosomal-recessive intellectual disability (ID). However, the molecular pathology underlying ID-associated TRMT1 mutations is unknown, since the biological role of the encoded TRMT1 protein...

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Détails bibliographiques
Publié dans:Mol Cell Biol
Auteurs principaux: Dewe, Joshua M., Fuller, Benjamin L., Lentini, Jenna M., Kellner, Stefanie M., Fu, Dragony
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640816/
https://ncbi.nlm.nih.gov/pubmed/28784718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00214-17
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