Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury

RATIONALE: TRPM2 (Transient Receptor Potential Melastatin-2) expressed in endothelial cells (ECs) is a cation channel mediating Ca(2+) entry in response to intracellular generation of adenosine diphosphoribose (ADPR), the TRPM2 ligand. OBJECTIVE: Because polymorphonuclear leukocytes (PMN) interactio...

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Vydáno v:Circ Res
Hlavní autoři: Mittal, Manish, Nepal, Saroj, Tsukasaki, Yoshikazu, Hecquet, Claudie M., Soni, Dheeraj, Rehman, Jalees, Tiruppathi, Chinnaswamy, Malik, Asrar B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640489/
https://ncbi.nlm.nih.gov/pubmed/28790198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311747
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