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Overexpression of dominant-negative Ikaros 6 isoform is associated with resistance to TKIs in patients with Philadelphia chromosome positive acute lymphoblastic leukemia

The clinical significance of the dominant-negative Ikaros 6 (DN-IK6) in the treatment of patients with Philadelphia-positive acute lymphoblastic leukemia (Ph(+)-ALL) with tyrosine kinase inhibitors (TKIs) remains elusive. In the present study, it was demonstrated that DN-IK6 was overexpressed in B-c...

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Detalhes bibliográficos
Publicado no:Exp Ther Med
Main Authors: Shao, Changfeng, Yang, Jie, Kong, Yirong, Cheng, Cong, Lu, Wei, Guan, Hongzai, Wang, Haiyan
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639309/
https://ncbi.nlm.nih.gov/pubmed/29042995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2017.4941
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