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Chronic morphine reduces the readily releasable pool of GABA, a presynaptic mechanism of opioid tolerance
KEY POINTS: Chronic treatment with opioids, such as morphine, leads to analgesic tolerance. While postsynaptic opioid tolerance is well documented, the involvement of presynaptic mechanisms remains unclear. We show that chronic morphine reduces the ability of periaqueductal grey (PAG) neurons to mai...
Shranjeno v:
| izdano v: | J Physiol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5638879/ https://ncbi.nlm.nih.gov/pubmed/28815604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274157 |
| Oznake: |
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