Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel

P2X receptors are non-selective cation channels gated by extracellular ATP, and the P2X7 receptor subtype plays a crucial role in the immune and nervous systems. Altered expression and dysfunctions of P2X7 receptors caused by genetic deletions, mutations, and polymorphic variations have been linked...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kasuya, Go, Yamaura, Toshiaki, Ma, Xiao-Bo, Nakamura, Ryoki, Takemoto, Mizuki, Nagumo, Hiromitsu, Tanaka, Eiichi, Dohmae, Naoshi, Nakane, Takanori, Yu, Ye, Ishitani, Ryuichiro, Matsuzaki, Osamu, Hattori, Motoyuki, Nureki, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638823/
https://ncbi.nlm.nih.gov/pubmed/29026074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00887-9
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