Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations

The aim of this study is to identify genetic variants that harbour signatures of recent positive selection and may facilitate physiological adaptations to hypobaric hypoxia. To achieve this, we conducted whole genome sequencing and lung function tests in 19 Argentinean highlanders (>3500 m) compa...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Eichstaedt, Christina A., Pagani, Luca, Antao, Tiago, Inchley, Charlotte E., Cardona, Alexia, Mörseburg, Alexander, Clemente, Florian J., Sluckin, Timothy J., Metspalu, Ene, Mitt, Mario, Mägi, Reedik, Hudjashov, Georgi, Metspalu, Mait, Mormina, Maru, Jacobs, Guy S., Kivisild, Toomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638799/
https://ncbi.nlm.nih.gov/pubmed/29026132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13382-4
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