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Bcl-x(L) mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages
Virulent Mycobacterium tuberculosis (Mtb) triggers necrosis in host Mφ, which is essential for successful pathogenesis. Here we demonstrate that necrosis of Mtb-infected Mφ is dependent on the action of the cytosolic kinase Receptor Interacting Protein 3 (RIPK3) and the mitochondrial Bcl-2 family me...
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| Publicado no: | Mucosal Immunol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5638669/ https://ncbi.nlm.nih.gov/pubmed/28401933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2017.12 |
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