SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERα-positive breast cancer through regulation of BRCA1

Tamoxifen is one of the most commonly employed endocrine therapies for patients with estrogen receptor α (ERα)-positive breast cancer. Unfortunately the clinical benefit is limited due to intrinsic and acquired drug resistance. We previously reported a genome-wide association study that identified c...

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Udgivet i:PLoS Genet
Main Authors: Cairns, Junmei, Ingle, James N., Wickerham, Lawrence D., Weinshilboum, Richard, Liu, Mohan, Wang, Liewei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638617/
https://ncbi.nlm.nih.gov/pubmed/28968398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007031
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