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Effects of forcefield and sampling method in all-atom simulations of inherently disordered proteins: Application to conformational preferences of human amylin

Although several computational modelling studies have investigated the conformational behaviour of inherently disordered protein (IDP) amylin, discrepancies in identifying its preferred solution conformations still exist between various forcefields and sampling methods used. Human islet amyloid poly...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Peng, Enxi, Todorova, Nevena, Yarovsky, Irene
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638406/
https://ncbi.nlm.nih.gov/pubmed/29023509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186219
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