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Brachyury-YAP regulatory axis drives stemness and growth in cancer

Molecular factors that define stem cell identity have recently emerged as oncogenic drivers. For instance, brachyury, a key developmental transcriptional factor, is also implicated in carcinogenesis, most notably of chordoma, through mechanisms that remain elusive. Here, we show that brachyury is a...

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Publicat a:Cell Rep
Autors principals: Shah, Sagar R., David, Justin M., Tippens, Nathaniel D., Mohyeldin, Ahmed, Martinez-Gutierrez, Juan C., Ganaha, Sara, Schiapparelli, Paula, Hamilton, Duane H., Palena, Claudia, Levchenko, Andre, Quiñones-Hinojosa, Alfredo
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637538/
https://ncbi.nlm.nih.gov/pubmed/29020634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.057
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