Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age

The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activati...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Immunol Cell Biol
Hlavní autoři: de Jong, Britt G, IJspeert, Hanna, Marques, Lemelinda, van der Burg, Mirjam, van Dongen, Jacques JM, Loos, Bruno G, van Zelm, Menno C
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636940/
https://ncbi.nlm.nih.gov/pubmed/28546550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2017.43
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky