Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following ischemic stroke

CD163 is a scavenger receptor expressed on innate immune cell populations which can be shed from the plasma membrane via the metalloprotease ADAM17 to generate a soluble peptide with lympho-inhibitory properties. The purpose of this study was to investigate CD163 as a possible effector of stroke-ind...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: O’Connell, Grant C., Tennant, Connie S., Lucke-Wold, Noelle, Kabbani, Yasser, Tarabishy, Abdul R., Chantler, Paul D., Barr, Taura L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636885/
https://ncbi.nlm.nih.gov/pubmed/29021532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13291-6
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